List of Selected Publications by Members of the Methods Hub


Snyder CF, Aaronson NK, Choucair AK, Elliott TE, Greenhalgh J, Halyard MY, Hess R, Miller DM, Reeve BB, Santana M. Implementing patient- reported outcomes assessment in clinical practice: a review of the options and considerations. Quality of Life Research 2012 Oct; 21(8):1305-14.Santana MJ, Feeny D. Framework to assess the effects of using patient-reported outcome measures in chronic care management. Qual Life Res. 2013 Dec 7. 

Santana MJ, Feeny D, Weinkauf J, Nador R, Kapasi A, Jackson K, Schafenacker M, Zuk D, Lien D.  The use of patient-reported outcomes become standard practice in the routine clinical care of lung-heart transplant patients.  Patient Relat Outcome Meas. 2010 Jul;1:93-105. 

Santana MJ, Feeny DH. Using the health utilities index in routine clinical care: process, feasibility, and acceptability: a randomized controlled trial.  Patient. 2009 Sep 1;2(3):159-67. 

Santana MJ, Feeny D, Jackson K, Weinkauf J, Lien D.  Improvement in health-related quality of life after lung transplantation.  Can Respir J. 2009 Sep-Oct;16(5):153-8. 

Santana MJ, Feeny D, Jackson K, Weinkauf J, Lien D.  Improvement in health-related quality of life after lung transplantation.  Can Respir J. 2009 Sep-Oct;16(5):153-8. 

Santana MJ, Feeny D, Johnson JA, McAlister FA, Kim D, Weinkauf J, Lien DC.  Assessing the use of Health-related quality of life measures in the routine Clinical care of lung transplant patients. Qual Life Res. 2010 Apr;19(3):371-9. 

Santana MJ, Feeny D.  The Importance of Measuring Health-related Quality of Life IHE Report, Institute of Health Economics,

Santana MJ.  Quality of Life in Lung Transplant Patients. Chapter Encyclopedia of Quality of Life and Well-Being Research.

Bainey KR, Norris CM, Gupta M, Southern D, Galbraith D, Knudtson ML, Graham MM. Altered health status and quality of life in South Asians with coronary artery disease. Am Heart J. 2011 Sep;162(3):501-6.

Sajobi TT, Lix LM, Clara I, Walker J, Graff LL, Rawsthorne P, Miller N, Rogala L, Carr R, Bernstein CN. Measures of relative importance for health-related quality of life. Quality of Life Research 2012; 21: 1 – 11.

Sikdar, K.C., Wang, P.P., MacDonald, D., Gadag, V. Diabetes and Its Impact on Health-related Quality of Life: A Life Table Analysis. Qual Life Res 2010; 19: 781-87.


Ghali WA, Pincus HA, Southern DA, Brien SE, Romano PS, Burnand B, Drosler SE, Sundararajan V, Moskal L, Forster AJ, Gurevich Y, Quan H, Colin C, Munier WB, Harrison J, Spaeth-Rublee B, Kostanjsek N, Ustun TB. ICD-11 for Quality and Safety: Overview of the WHO Quality and Safety Topic Advisory Group. IJQHC 2013 

Agarwal V, Podchiyska, Goel V, Leung T, Minty E, Sweeney T, Gyang E, Shah N. (2015). Learning Statistical Models of Phenotypes Using Noisy Labeled Training Data. Journal of American Medical Informatics Association : JAMIA. 3/1/2015

Mortensen JM, Minty EP, Januszyk M, Sweeney TE, Rector AL, Noy NF, Musen, MA. Using the wisdom of the crowds to find critical errors in biomedical ontologies: a study of SNOMED CT. Journal of the American Medical Informatics Association: JAMIA 2015 May;22(3):640-8.

Minty E, Cusumano-Towner M, Ghali W.  Terminologies and ontologies using a Graphical UI: An exploration of common underpinnings of SNOMED and ICD.  Submitted to WHO Terminology and Standards Unit, October 2013.


Southern DA, Roberts B, Edwards A, Dean S, Norton P, Svenson LW, Larsen E, Sargious P, Lau DC, Ghali WA. Validity of administrative data claim-based methods for identifying individuals with diabetes at a population level. Can J Public Health. 2010 Jan-Feb;101(1):61-4.

Li, B, Quan H, Fong A, Lu M, 2006, Assessing record linkage between health care and Vital Statistics databases using deterministic methods, BMC Health Services Research 6: 48.

Sikdar, K.C., Dowden, J., Alaghehbandan, R., MacDonald, D., Wang, P.P., Gadag, V. Adverse drug reactions in elderly hospitalized patients: A 12-year population-based retrospective cohort study. Ann Pharmacother 2012; 46:960-971.


M Greiver, B Aliarzadeh, C Meaney, R Moineddin, C.A. Southgate, D.T. Barber, D.G. White, K.B. Martin, T Iktiar, T Williamson. Are we asking patients if they smoke? Missing information on tobacco use in Canadian EMRs. American Journal of Preventive Medicine (AJPM) 18 May 2015.

*Rigobon A, Khan S, Barber D, Biro S, Morkem R, Janssen I, Birtwhistle R, Williamson T. Adult Obesity Prevalence in Primary Care Users: An Exploration Using Canadian Primary Care Sentinel Surveillance Network (CPCSSN) Data. Canadian Journal of Public Health 2015. *IN PRESS*

N Coleman, G Halas, W Peeler, N Casaclang, T Williamson, A.K. Title. From Patient Care to Research:  A validation study examining the factors contributing to data quality in a Primary Care Electronic Medical Record Database. BMC Family Practice. December, 2014.

Birtwhistle R, Williamson T. Primary care electronic medical records: a new data source for research in Canada. CMAJ, November 2014.

Williamson T, Green M, Birtwhistle RV, Khan S, Garies S, Wong ST, Natarajan N, Manca D, Drummond N. Validating the eight CPCSSN case definitions for chronic disease surveillance in a primary care database of electronic medical records. Annals of Family Medicine, 2014; 12(4):367-372.

Williamson T, Lévesque L, Morkem R, Birtwhistle R. CPCSSN’s role in improving pharmacovigilance. Canadian Family Physician, 2014; 60(7):678-678.

Lukewich J, Corbin R, VanDenKerkhof EG, Edge DS, Williamson T, Tranmer JE. Identification, summary and comparison of tools used to measure organizational attributes associated with chronic disease management within primary care settings. Journal of Evaluation in Clinical Practice, 2014.

Keshavjee K, Williamson T, Martin K, Truant R, Aliarzadeh B, Ghany A, Greiver M. Getting to usable EMR data. Canadian Family Physician, 2014; 60(4):392-392.

Greiver M, Williamson T, Bennett TL, Drummond N, Savage C, Aliarzadeh B, Birtwhistle RV. Developing a method to estimate practice denominators for a national Canadian electronic medical record database. Family Practice, 2013; 30(3):347-354.

Kadhim-Saleh AJ, Green M, Williamson T, Hunter D, Birtwhistle RV. Validation of the Diagnostic Algorithms of 5 Chronic Conditions in the Canadian Primary Care Sentinel Surveillance Network (CPCSSN): A Kingston Practice-based Research Network (PBRN) Report. The Journal of the American Board of Family Medicine, 2013; 26(2):159-167.

*Lix, L.M., Yao, X., Kephart, G., Quan, H., Smith, M., Kuwornu, J.P., Kroeker, K., Manoharan, N., Kouokam, W., Sikdar, K.C. A prediction model to estimate completeness of electronic physician claims databases. BMJ Open. *IN PRESS*.


Sajobi TT, Zhang Y, Menon BK, Demchuck AM, Goyal M, Broderick J, Hill MD. Effect Size Estimates for the ESCAPE trial: Proportional Odds Regression versus other statistical methods. Stroke 2015. [Epub ahead of print]

Lu M, Sajobi TT, Lucyk K, Lorenzetti D, Quan H. A systematic review of risk adjustment models of hospital length of stay. Medical Care 2015; 53(4): 355 – 365.

Sajobi TT, Lix LM, Singh G, Lowerison M, Engbers J, Mayo NE. Identifying reprioritization response shift in a stroke caregiver population: A comparison of missing data methods. Quality of Life Research 2015; 24(3): 529-540.

Sajobi TT, Fiest KM, Wiebe S. Changes in quality of life after epilepsy surgery: The role of  reprioritization response shift. Epilepsia 2014; 55(9), 1331 – 1338.

Schwartz CE., Sajobi TT, Verdam MG, Sebille V, Lix L, Guilleux A, Sprangers MAG. Methods variation in the impact of missing data on response shift detection. Quality of Life Research 2015; 24(3): 521-528.

Schwartz CE, Ahmed S, Sawatzky R, Sajobi TT, Mayo N, Finkelstein, J, Lix L, Sprangers MAG. Guidelines for secondary analysis in search of response shift. Quality of Life Research 2013; 22: 2663 – 2673.

Schwartz CE, Sajobi TT, Lix LM, Quaranto BR, Finkelstein JA. Changing values, changing outcomes: The influence of reprioritization response shift on outcome assessment after spine surgery. Quality of Life Research 2013; 22: 2255 – 2264.

Lix LM, Sajobi TT, Sawatzky R, Liu J, Mayo NE, Huang Y, Graff LA, Walker JR, Ediger J, Clara I, Sexton K, Carr R., Bernstein CN. Relative importance measures for reprioritization response shift. Quality of Life Research 2013; 22: 695 – 703.

Sajobi TT, Lix LM, Dansu BM, Laverty WH., Li L. Robust descriptive discriminant analysis for  repeated measures data. Computational Statistics and Data Analysis 2012; 56(9): 2782– 2794.

Sajobi TT, Lix LM, Laverty WH, Li L. Discriminant analysis for repeated measures data: effects of mean and covariance misspecification on bias and error in discriminant function coefficients. Journal of Modern Applied Statistical Methods 2011; 10: 571 – 582.

Lix LM, Sajobi TT. Discriminant analysis for repeated measures data: a review. Frontiers in Quantitative Psychology and Measurement 2010;1: 1 – 9.

Lix LM, Sajobi TT. Testing multiple outcomes in repeated measures data. Psychological Methods 2010; 15: 268 – 280.

Williamson T, Eliasziw M, Fick GH. Log-binomial models: exploring failed convergence. Emerging Themes in Epidemiology, 2013; 10:14

de Leon AR, Soo A, Williamson T. Classification with discrete and continuous variables via general mixed-data models. Journal of Applied Statistics, May 2010; 38(5): 1021-1032.


Lu, M, 1999, Separating the True Effect from Gaming in Incentive-Based Contracts in Health Care, Special Issue on The Industrial Organization of Health Care III,  Journal of Economics & Management Strategy 8 (3): 383-432.

Lu, M, 1999, The Productivity of Mental Health Care: An Instrumental Variable Approach, Journal of Mental Health Policy and Economics 2 (2): 59-71.

Lu, M, Ching-to AM, 2002, Consistency in Performance Evaluation Reports and Medical RecordsJournal of Mental Health Policy and Economics 5 (4): 141-152.

Lu, M, Ching-to AM, Lasheng Y, 2003, Risk Selection and Matching under Performance-Based Contracting, Health Economics 12 (5): 339-354.


Lu, M, Moritz S, Sykes L, Lorenzetti D, Strauss S, Quan H, A systematic review of interventions to increase cancer screening uptake among Asian women, BMC Public Health 2012, 12:413


Southern DA, Poole J, Patel A, Waters N, Pilote L, Hull RD, Ghali WA (2014). Health system capacity and infrastructure for adopting innovations to care for patients with venous thromboembolic disease.  Open Medicine, 8(2).


Lorenzetti DL, Topfer LA, Dennett L, Clement F.  Value of databases other than MEDLINE for rapid health technology assessments. Int J Technol Assess Health Care 2014 30(2): 173-178.

Lorenzetti DL, Ghali WA.  Reference management software for systematic reviews and meta-analyses: an exploration of usage and usability. BMC Medical Research Methodology. 2013, 13:141.

Brien SE, Lorenzetti DL, Lewis S, Kennedy J, Ghali WA.  Overview of a formal scoping review on health system report cards.  Implementation Science 2010, 5:2